Pyrantel tartrate

Research use only, not for human use.

Pyrantel tartrate is an antinematodal thiophene; and can elicit spastic muscle paralysis in parasitic worms due to prolonged activation of the excitatory nicotinic acetylcholine (nACh) receptors on body wall muscle.

Pyrantel tartrate is an antinematodal thiophene; and can elicit spastic muscle paralysis in parasitic worms due to prolonged activation of the excitatory nicotinic acetylcholine (nACh) receptors on body wall muscle.(In Vitro):Pyrantel tartrate (10 nM-10 μM; 72 h) shows good anti-A. suum and (0-168.2 M; 72 h) anti-N. americanus activity.(In Vivo):Pyrantel tartrate (10 mg/kg; p.o.; single) reduces the worms in A. ceylanicum-infected hamsters, with the worm burden reduction of 87.2% and worm expulsion rate of 63.4%.

Pyrantel tartrate (10 nM-10 μM; 72 h) shows good anti-A. suum and (0-168.2 M; 72 h) anti-N. americanus activity. Cell Viability AssayCell Line:A. suum Concentration:10 nM-10 μM Incubation Time:72 h Result:Inhibited A. suum with a pEC50 value of 7.24.Cell Viability Assay Cell Line:N. americanus Concentration:0-168.2 M (0-100 μg/mL)Incubation Time:72 h Result:Inhibited third-stage larvae and adult of N. americanus with IC50 values of 2.0 and 7.6 mg/mL, respectively.

Pyrantel tartrate (10 mg/kg; p.o.; single) reduces the worms in A. ceylanicum-infected hamsters, with the worm burden reduction of 87.2% and worm expulsion rate of 63.4%. Animal Model:Male Syrian Golden hamsters (3-week-old; A. ceylanicum-infected).Dosage:10 mg/kg Administration:Oral administration; single.Result:Exhibited worm burden reduction and worm expulsion rates of 87.2% and 63.4%, respectively.

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Others

Other Targets

Others

Infection

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33401-94-4

356.39

C15H20N2O6S

>98% (HPLC)

DMSO: 10 mM

CN1CCCN=C1/C=C/C2=CC=CS2.[C@@H]([C@H](C(=O)O)O)(C(=O)O)O

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(-20℃)

With Ice Pack

≥ 2 years